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Year : 2015  |  Volume : 11  |  Issue : 41  |  Page : 170-175

Obtainment of pellets using the standardized liquid extract of Brosimum gaudichaudii Trécul (Moraceae)

1 Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil
2 Laboratory of Research, Development and Pharmacotechnical, Faculty of Pharmaceutical Science from Ribeirão Preto, University of São Paulo, Brazil

Correspondence Address:
Omar Paulino Silva Filho
Laboratório de Pesquisa, Desenvolvimento e Inovação em Bioprodutos, Faculdade de Farmácia, Universidade Federal de Goiás, praça universitária, 1166, Setor Leste Universitário, CEP 74.605-220, Goiânia, Goiás
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.149734

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Background : The standardized liquid extract of Brosimum gaudichaudii Trécul is an alternative for the treatment of vitiligo. There is a shortage of solid oral dosage forms developed from standardized extracts of this plant specie. Objective: This study is aimed to obtain pellets with a standardized liquid extract of B. gaudichaudii. Results: The standardized liquid extract of B. gaudichaudii was obtained through maceration and percolation with a 55% ethanol-water solution (v/v). Pellets were obtained through a mixture of extract of 500 g of B. gaudichaudii standardized extract, 500 g of microcrystalline cellulose PH101 and 10 g of hydroxypropyl methylcellulose K100. The pellets obtained presented a homogeneity yield of 92%, aspect ratio of 1.16 ± 0.65, shape fator eR of 0.35 ± 0.09 and Feret diammeter of 0.87 ± 0.27. These pellets were coated with a suspension composed of titanium dioxide, aluminum red lacquer, ethyl cellulose, talc and magnesium stearate. Before the photostability test, the uncoated pellets showed psoralen content equal to 0.13 ± 0.01% and to the 5-MOP was 1.40 ± 0.27%. After exposure to one level (3 J.cm -2 ) of UVB irradiation the uncoated pellets presented a degradation of 2.16% of psoralen and 8.1% of 5-MOP. After exposure to three levels (10, 20 and 30 J.cm -2 ) of UVA irradiation the uncoated pellets exhibited photodegradation of 9.78, 17.64, 24.21% of psoralen and 18.95, 23.68, 28.48% for 5-MOP. The coated pellets where unaffected after photostability test. Conclusion: Pellets were obtained with the standardized liquid extract of B. gaudichaudii and coating is a technological alternative to ensure the stability of the formula.

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