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Year : 2014  |  Volume : 10  |  Issue : 40  |  Page : 402-409

Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice

1 Molecular Pathology Laboratory, Hunan University of Chinese Medicine; Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardiocerebral Diseases, Hunan, China
2 Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques Changsha 410208, Hunan, China
3 Molecular Pathology Laboratory, Hunan University of Chinese Medicine, Hunan, China

Correspondence Address:
Chang-Qing Deng
Molecular Pathology Laboratory, Hunan University of Chinese Medicine, Changsha 410208
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Source of Support: National Natural Science Foundation of China (No. 81102557); Doctoral Program Foundation of Higher Education of China (No. 20104323110001); Aid Project for Innovation Platform Open Fund of Hunan province university (No. 11K050); Key Project of Administration of traditional Chinese Medicine of Hunan province (No. 201301); General Project of Education Bureau of Hunan Province (No. 11C0963); Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province for gRelated research on prevention and treatment of cardio.cerebrovascular diseases with integrated traditional Chinese and Western Medicineh, Hunan Province Natural Science Innovation Group for gFundamental research of Chinese medicine on prevention and treatment of cardio.cerebrovascular diseasesh, Conflict of Interest: None

DOI: 10.4103/0973-1296.141765

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Background: Astragalus and Panax notoginseng are traditional Chinese Medicines used for the treatments of ischemic cerebrovascular disease, being often combined together in China and achieving a good effect. Objective: The objective of this study is to investigate the effects of astragaloside-IV (AST-IV) (the effective component of Astragalus) combined with ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 (the effective components of P. notoginseng) on oxidative stress injury after cerebral ischemia-reperfusion in mice, and to explore the mechanisms through nuclear factor-erythroid 2-related factor-2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway. Materials and Methods: C57BL/6 mice were randomly grouped after treated for 3 days, the model of cerebral ischemia-reperfusion injury was established, and the brain tissues were detected. Results: AST-IV combined with ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 could increase significantly the survival rate of nerve cell; decrease the contents of malondialdehyde, nitric oxide, increase the activity of superoxide dismutase and the level of glutathione; Nrf2 was down-regulated in the cytoplasm while up-regulated in nucleus, nuclear translocation rate raised as well as HO-1 messenger ribonucleic acid and protein expressions increased. The effects of four active components combination were better than those of the active components alone. Conclusion: Active components of Astragalus and P. notoginseng had the effects against cerebral ischemia-reperfusion injury, which were related to the antioxidative stress after cerebral ischemia-reperfusion. AST-IV combined with ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 could strengthen the antagonism effects on ischemia-reperfusion and oxidative stress injury, the mechanism underlying might be associated with jointly activating Nrf2/HO-1 signaling pathway after cerebral ischemia-reperfusion.

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