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Year : 2014  |  Volume : 10  |  Issue : 38  |  Page : 377-382

Anti-inflammatory effects of Cryptotympana atrataFabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

1 Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, South Korea
2 Department of Herbology, College of Korean Medicine, Wonkwang University, Jeonbuk, South Korea
3 Department of Oral Pathology, School of Dentistry, Pusan National University, Gyeongnam, South Korea

Correspondence Address:
Hyungwoo Kim
Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan City, Gyeongnam, 626-870
South Korea
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Source of Support: Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012011676)., Conflict of Interest: None

DOI: 10.4103/0973-1296.133288

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Background: The slough shed of Cryptotympana atrata Fabricius is widely used to treat skin diseases in China, Japan, and Korea. Objective: To investigate the anti-inflammatory effects of C. atrata on contact dermatitis. Materials and Methods: We investigated the effects of C. atrata methanol extract (MECA) on ear swelling, histophathological changes and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mice. Results: Topical application of MECA effectively inhibited enlargement of ear swelling (30 and 100 μ/ear, P < 0.05; 300 μg/ear, P < 0.01). MECA treatment also inhibited hyperplasia, spongiosis (100 and 300 μg/ear, P < 0.001), and immune cell infiltration (30 μg/ear, P < 0.05; 100 and 300 μg/ear, P < 0.001) induced by DNFB. In addition, treatment with MECA suppressed the increase in the levels of TNF-α (P < 0.05), IFN-g (3, 100 μg/ear, P < 0.05; 300 μg/ear, P < 0.01), and IL-6 (100 μg/ear, P < 0.05; 300 μg/ear, P < 0.01) production. Conclusion: These data suggest that MECA has the potential for use in the treatment of inflammatory skin diseases, including CD. Moreover, the results presented herein indicate that anti-inflammatory actions of MECA are mediated by decreasing production of TNF-α, IFN-γ, and IL-6 in inflamed tissues.

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