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Year : 2013  |  Volume : 9  |  Issue : 33  |  Page : 76-80

Secondary metabolites from the stem of Ravenia spectabilis Lindl

1 Organic Research Laboratory, Department of Chemistry, Faculty of Science, Jagannath University, Dhaka-1100, Bangladesh
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
3 Chemical Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories Dhaka, Dhaka-1205, Bangladesh

Correspondence Address:
Choudhury M Hasan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.108147

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Background: Ravenia spectabilis is a medium tall shrub found widespread in South America. It also found in India, Pakistan, Bangladesh etc. Few alkaloid and steroid compounds were reported from the plant previously. Materials and Methods: Methanol extract from the stems of Ravenia spectabilis were partitioned into n-hexane, carbon tetrachloride, chloroform and aqueous soluble fractions, respectively. The crude methanol extract, carbon tetrachloride fraction and chloroform fraction were fractionated by column chromatography of Silica gel and Sephadex LH-20 for isolation and purification of compounds. The structures of the isolated compounds were determined by extensive NMR spectral analysis, including 2D NMR, mass spectroscopy etc. Results: Ten compounds, γ-fagarine (1), ravenoline (2), N-methyl atanine (3),2,3,3,5-tetramethyl-2,3,4,5- tetrahydrofurano [3,2-c] quinolin-4-one (4), arborinine (5), 3-geranyl indole (6), atanine (7), steroids sitosta-4-en- 3-one (8), stigmasterol (9) and 3-methoxy-4-hydroxy cinnamic acid (10) were isolated from the stems of Ravenia spectabilis. Conclusion: Compounds N-methyl atanine (3), 2,3,3,5-tetramethyl-2,3,4,5-tetrahydrofurano [3,2-c] quinolin-4-one (4) , 3-geranyl indole (6), sitosta-4-en-3-one (8) and 3-methoxy-4-hydroxy cinnamic acid (10) were isolated from this plant for the first time. 3-geranyl indole (6) was also isolated second time from natural sources.

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