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Year : 2011  |  Volume : 7  |  Issue : 28  |  Page : 314-319

Antioxidative effects of cinnamomi cortex: A potential role of iNOS and COX-II

Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea

Correspondence Address:
Sung-Jin Kim
Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul 130-701
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.90412

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Background: Cinnamomi cortex has wide varieties of pharmacological actions such as anti-inflammatory action, anti-platelet aggregation, and improving blood circulation. In this study, we tested to determine whether the Cinnamomi cortex extract has antioxidant activities. Materials and Methods: Antioxidative actions were explored by measuring free radical scavenging activity, NO levels, and reducing power. The mechanism of antioxidative action of Cinnamomi cortex was determined by measuring iNOS and COX-II expression in lipopolysaccharide (LPS) stimulated Raw cells. Results: Seventy percent methanolic extract of Cinnamomi cortex exerted significant 1,1­diphenyl-­2-­picrylhydrazyl (DPPH) free radicals and NO scavenging activities in a dose-dependent manner. More strikingly, the Cinnamomi cortex extract exerted dramatic reducing power activity (13-fold over control). Production of iNOS induced by LPS was significantly inhibited by the Cinnamomi cortex extract, suggesting that it inhibits NO production by suppressing iNOS expression. Additionally, COX-2 induced by LPS was dramatically inhibited by the Cinnamomi cortex extract. Conclusion: These results suggest that 70% methanolic extract of Cinnamomi cortex exerts significant antioxidant activity via inhibiting iNOS and COX-II induction.

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