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Year : 2010  |  Volume : 6  |  Issue : 22  |  Page : 79-82

Chemical composition and resistance-modifying effect of the essential oil of Lantana camara linn

1 Programa de Pos-Graduacao em Bioprospeccao Molecular, Departamento de Química Biologica, Laboratorio de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Antonio Luiz 1161, Pimenta, 63105-000, Crato-CE, Brazil
2 Vice-Reitoria de Pesquisa e Pos-Graduacao, Universidade de Fortaleza, Av. Washington Soares 1321, Edson Queiroz, 60811-905, Fortaleza-CE, Brazil
3 Departamento de Química, Universidade Federal do Piaui, Campus Universitário Ministro Petronio Portella, 64049-550, Bairro Ininga,Teresina-PI, Brazil

Correspondence Address:
Jose Galberto M Costa
Carolina Sucupira, 716 Crato, Ceara
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Source of Support: Financial support from CAPES, CNPq and FUNCAP, and to UFPI for the chromatograms, Conflict of Interest: None

DOI: 10.4103/0973-1296.62890

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In this work, the chemical constituents, antibacterial and modulatory activities of the essential oil of Lantana camara Linn were studied. The essential oil was extracted from the leaves of L. camara by hydrodistillation method using Clevenger's apparatus and its chemical constituents were separated and identified by GC-MS, and the relative content of each constituent was determined by area normalization. Among the 25 identified components, bicyclogermacrene (19.42%), isocaryophyllene (16.70%), valecene (12.94%) and germacrene D (12.34%) were the main constituents. The oil was examined to antibacterial and modulatory activities against the multiresistant strains of Escherichia coli and Staphylococcus aureus by microdilution test. The results show an inhibitory activity to E. coli (MIC 512 μg/ml) and S. aureus (MIC 256 μg/ml). The synergism of the essential oil and aminoglycosides was verified too, with significant reduction of MICs (7Χ, 1250-5 μg/ml) against E. coli. It is suggested that the essential oil of Lantana camara Linn could be used as a source of plant-derived natural products with resistance-modifying activity.

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