| RESEARCH ARTICLE |
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| Year : 2009 | Volume
: 5
| Issue : 19 | Page : 46-50 |
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Synergistic effect of Withania somnifera dunal and L-dopa in the inhiition of haloperidol-induced catalepsy in mice
Lal Gupta Girdhari, Chand Rana Avtar
Department of Pharmacology, B. N. College of Pharmacy, Udaipur-313 002 (Rajasthan), India
Correspondence Address:
Chand Rana Avtar
Department of Pharmacology, B. N. College of Pharmacy, Udaipur-313 002 (Rajasthan)
India
 Source of Support: None, Conflict of Interest: None  | Check |
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The possible synergism between WS and dopamine precursor L-dopa to inhibit haloperidol-induced catalepsy was investigated by using standard bar test in mice. The effect of WS (20-200 mg/kg, oral), L-dopa (20-200 mg/kg, oral) plus carbidopa and combination of subeffective doses of WS (20 or 50 mg/kg, oral) prior to L-dopa (20, 50 or 100 mg/kg, oral) plus carbidopa was assessed in haloperidol (1 mg/kg, i.p.) induced catalepsy. L-dopa and carbidopa combination was always administered in 10:1 ratio. WS (100 or 200 mg/kg, oral) and L-dopa (50, 100 or 200 mg/kg, oral) plus carbidopa treated groups showed a dose dependent reduction in cataleptic scores. Subeffective doses of WS (20 or 50 mg/kg, oral) prior to L-dopa (20, 50 or 100 mg/kg, oral) also potentiated the anticataleptic effect of L-dopa. These results indicate that subeffective doses of WS enhance the anticataleptic actions of L-dopa and the possibility of using WS as adjunctive therapy to reduce the doses and the adverse effects of dopamine precursor in Parkinson's disease. |
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