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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 49  |  Page : 76-80

Obtaining a dry extract from the Mikania laevigata leaves with potential for antiulcer activity


1 Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia–Goiás, Brazil
2 Universidade Federal de Goiás, Instituto de Ciências Biológicas-Laboratório de Farmacologia de Produtos Naturais–Goiânia, Goiás, Brazil

Correspondence Address:
Maria Teresa Freitas Bara
Universidade Federal de Goiás, Faculdade de Farmácia, Laboratório de Pesquisa de Produtos Naturais, Rua esquina com 5ª avenida, s/nº – Setor Universitário, Goiânia - GO, Brazil
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.197640

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Background: Mikania laevigata leaves are commonly used in Brazil as a medicinal plant.Objective: To obtain hydroalcoholic dried extract by nebulization and evaluate its antiulcerogenic potential.Materials and Methods: Plant material and hydroalcoholic extract were processed and analyzed for their physicochemical characteristics. A method using HPLC was validated to quantify coumarin and o-coumaric acid. Hydroalcoholic extract was spray dried and the powder obtained was characterized in terms of its physicochemical parameters and potential for antiulcerogenic activity.Results: The analytical method proved to be selective, linear, precise, accurate, sensitive, and robust. M. laevigata spray dried extract was obtained using colloidal silicon dioxide as adjuvant and was shown to possess 1.83 ± 0.004% coumarin and 0.80 ± 0.012% o-coumaric acid. It showed significant antiulcer activity in a model of an indomethacin-induced gastric lesion in mice and also produced a gastroprotective effect.Conclusion: This dried extract from M. laevigata could be a promising intermediate phytopharmaceutical product. Abbreviations used: DE: M. laevigata spray dried extract, HE: hydroalcoholic extract


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