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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 20  |  Page : 301-305

Hypolipidemic Effects of Seed Extract of Celery (Apium graveolens ) in Rats


1 Department of Biological Sciences, Faculty of Science, Al al-bayt University, Mafraq, Jordan
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alfateh University of Medical Sciences, Tripoli, Libya, P.O.Box 13620, Libya
3 Department of Biological Sciences, Faculty of Science, University of Jordan, Amman 11942, Jordan
4 Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan

Correspondence Address:
Talal Aburjai
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942
Jordan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.58149

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The hypolipidemic effects of ethanol extract of A. graveolens L. (Apiaceae) were investigated. Forty adult male albino rats weighing about 260 g each, were divided into four groups (n = 10). Experimental animals were gavaged at doses of 213 and 425 mg/kg body wt. for sixty consecutive days. Extract showed a significant decrease (p<0.05) of serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-c), and significant increase (p<0.05) in high-density lipoprotein cholesterol (HDL-c) in the treated groups. The oral administration of ethanol extract of A. graveolens revealed good hypolipideamic effects in adult male albino rats. The results have given a considerable agreement to the traditional use of A. graveolens in the treatment of hyperlipidemia; it could possibly lead to appropriate changes in blood lipid profiles.


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